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Testosterone side effect
Although Testosterone itself may present side effects that other modified analogues and derivatives have avoided (such as Estrogenic side effects, for example), Testosterone overall is considered the safest anabolic steroid if only for the reason that it is the anabolic hormone that the human body endogenously produces naturally. It then stands to reason that the human body is well accustomed to the effects of Testosterone on its cells and systems, and enough research has been conducted on Testosterone and its effects on the body that nearly all of the knowledge of Testosterone Propionate side effects possible are known to man, and this information is easily accessible. There is in fact far more abundant solid scientific data in the form of clinical studies and information on Testosterone and its different ester types than any other anabolic steroid in existence.
This is in contrast with other modified analogues of Testosterone. While as mentioned above, these modified analogues may avoid certain side effects that are inherently a part of Testosterone itself, they often may exhibit odd side effects and odd behavior unknown to science due to its modifications that essentially create an entirely new anabolic steroid. This odd behavior would never be exhibited by Testosterone itself, being that Testosterone being the most natural anabolic steroid to the human body. The hidden or odd side effects associated with various analogues/derivatives should therefore not be experienced with Testosterone (compared to a very mysterious compound, such as Anadrol or Trenbolone, for example).
With this having been established, Testosterone is not without its share of potential side effects. But it is our almost complete understanding of this compound that allows Testosterone Propionate side effects to be efficiently understood and dealt with.
Estrogenic Side Effects
Testosterone itself possesses a moderate level of Estrogenic activity, whereby it holds a moderate affinity to bind to the aromatase enzyme (the enzyme responsible for the conversion of Testosterone into Estrogen). Therefore, a moderate level of aromatization is to be expected with Testosterone use. The result can be significant rises in Estrogen levels resulting from the conversion of Testosterone into Estrogen, especially when Testosterone Propionate it utilized at bodybuilding doses and doses required for performance and physique enhancement. Estrogenic Testosterone Propionate side effects should not be ignored for this reason, and the rate of aromatization usually always holds a direct correlation with the doses utilized. It stands to reason that increasingly higher doses will usually be met with an increase in aromatization of Testosterone into Estrogen. Individuals should then understand that bodybuilding doses of Testosterone will often generate significant amounts of aromatization that must be dealt with in some way. Individuals can elect to use an aromatase inhibitor, which serves to disable the aromatase enzyme so that Testosterone cannot be converted into Estrogen, effectively controlling Estrogen increases as the root cause. The other possible option is the use of a SERM (Selective Estrogen Receptor Modulator) such as Nolvadex, which instead acts to block Estrogen from attaching to receptor sites in breast tissue. SERMs such as Nolvadex will only serve to remedy the issue of gynecomastia caused by Estrogen, and will not actually reduce serum Estrogen levels in the body – an aromatase inhibitor is what is required for such an effect. Estrogenic side effects include the following: water retention and bloating, blood pressure elevations (as a result of the water retention), increased possible fat retention/gain, and gynecomastia.
Androgenic Side Effects
Being that Testosterone is the prime male androgen, Testosterone Propionate side effects do include the aspect of androgenic side effects as well. It also undergoes conversion into an even stronger androgenic metabolite, Dihydrotestosterone (DHT). Testosterone possesses an androgenic strength rating of 100, which serves to exhibit a considerable amount of androgenic activity in the body. However, Testosterone Propionate side effects in the area of androgenicity have more to do with the fact that Testosterone is converted into the aforementioned stronger and more potent androgen Dihydrotestosterone (DHT) via the 5-alpha reductase (5AR) enzyme.
The 5-alpha reductase enzyme is present in large amounts in certain tissues, such as the scalp, prostate, and the skin. When Testosterone reaches these tissues, it undergoes a high rate of reduction into its more potent androgenic metabolite DHT. It is DHT that is responsible for the greater severity of androgenic side effects. Ancillary drugs such as Proscar or Dutasteride can be utilized to effectively inhibit the 5-alpha reductase enzyme and thereby eliminate DHT at the root of its cause. This will not, however, completely eliminate androgenic side effects due to the fact that Testosterone itself possesses an androgenic strength rating of 100 and will still act as an androgen in various tissues throughout the body even if the potential to convert into DHT is eliminated or reduced.
An alternative (or an adjunct) to 5AR inhibitors such as Proscar is the topical use of Nizoral 2% shampoo, where its active ingredient Ketoconazole acts as a topical DHT blocker in skin and scalp, effectively reducing the probability of androgens triggering male pattern baldness as well as acne breakouts caused by increased oily skin. Androgenic side effects include: increased sebum secretion (oily skin), increased bouts of acne (linked to increased sebum secretion), bodily and facial hair growth, benign prostatic hypertrophy (BPH), and the increased risk of triggering Male Pattern Baldness (MPB) in individuals that possess the genetic trait required for the condition to manifest itself.
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